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Antibiotic work either to stop or to kill bacteria. They all have been modified to influence the selected bacteria, but not the cells in the body. Considering that bacteria are single-cell organisms, they pass into our immune systems, reproduce inside our bodies and cause disease. If we want to kill the bacteria and eliminate the disease, we have to take antibiotics. But, different types of antibiotics act differently: some inhibit the ability of bacteria to turn glucose into energy and construct the cell wall; others act only on the cell-wall-building mechanism of bacteria...
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Later on, another group of pathogens became important: In critically ill patients whose immunity was diminished and whose natural barriers were broken with multiple invasive devices or procedures, the native skin or mucosal colonizing flora asserted: coagulase-negative staphylococci, enterococci, Candidae. Despite some new discoveries (teicoplanin, triazol antimycotics), the account of anti-infective drugs in this field is unsatisfactory. S.A.Waksman introduced the term .antibioticЃg in 1942. In forties to sixties, the term ЃgantibioticЃh was clearly differed from the term Ѓgchemotherapeutic drugЃh: Antibiotics were natural drugs produced by several fungi or bacteria. Chemotherapeutic drugs were man-made substances. Nevertheless the differences were abolished after chemical synthesis of some antibiotics has been realized and new drugs have been developed from the natural products with binding various side chains to the basic structure. - In addition, absorption of beta-lactams from the gastrointestinal tract is limited. The majority of beta-lactams has been prepared only in parenteral form. Esterification of the original drug is sometimes performed in order to facilitate the absorption; these esterified beta-lactams should be administrated with food.
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