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Antibiotic work either to stop or to kill bacteria. They all have been modified to influence the selected bacteria, but not the cells in the body. Considering that bacteria are single-cell organisms, they pass into our immune systems, reproduce inside our bodies and cause disease. If we want to kill the bacteria and eliminate the disease, we have to take antibiotics. But, different types of antibiotics act differently: some inhibit the ability of bacteria to turn glucose into energy and construct the cell wall; others act only on the cell-wall-building mechanism of bacteria...
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Many new antibiotics with high level of compatibility for patients were introduced for treatment of community infections as well. Oral cephalosporins, new macrolides, doxycyclin and fluoroquinolones are examples of these modern and sometimes fashional . drugs. Nevertheless, production of the easy-to-take and relatively safe antibiotics often led to the overuse and rapid rise in resistance in bacterial populations. Beta-lactams are spread mostly in the extracellular space. The penetration across biological barriers is limited, sometimes it can be reversed with higher dosing. Intracellular penetration of beta-lactams is poor., Any allergy to penicillins or cephalosporins should be proven with examination of antibody level in blood. The true allergy to any penicillin drug must be interpreted as allergy to all penicillins. The allergy to a cephaloporin need not necessarily imply the allergy to all other cephalosporins (the reaction can be targeted against the complicated side chain of drug). The cross-allergy between penicillines and cephalosporins is possible but not frequent. The probability of allergy to cephalosporins in patients allergic to penicillins was estimated 5-10%. Therefore, cephalosporines can be given with caution in patients with history of a mild penicillin allergy (exanthema). On the other hand, allergy to cephalosporins implies high probability of cross-allergy to penicillins.
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